Co-injecting hyaluronidase with an IM injection mainly results in what effect?

Co-injecting hyaluronidase with an IM injection mainly results in what effect?

• A. Decreases rate of absorption by constricting blood vessels
• B. No change in absorption
• C. Increases rate of absorption by breaking down connective tissue
• D. Causes tissues to swell and trap the drug

Answer: (C)

Hyaluronidase acts as a spreading factor by breaking down hyaluronic acid in the extracellular matrix of connective tissue. This lowers tissue viscosity and increases permeability, letting the injected drug diffuse more readily into blood vessels and enter systemic circulation. So the main effect is an increased rate of absorption. It doesn’t constrict vessels or leave absorption unchanged, and it doesn’t trap the drug in tissue—though minor local swelling can occur, the intended outcome is faster, enhanced absorption.

Hyaluronidase acts as a spreading factor by breaking down hyaluronic acid in the extracellular matrix of connective tissue. This lowers tissue viscosity and increases permeability, letting the injected drug diffuse more readily into blood vessels and enter systemic circulation. So the main effect is an increased rate of absorption. It doesn’t constrict vessels or leave absorption unchanged, and it doesn’t trap the drug in tissue—though minor local swelling can occur, the intended outcome is faster, enhanced absorption.